A 36-year-old woman with advanced HIV was found to be carrying the novel coronavirus for 216 days, during which the virus accumulated more than 30 mutations, a new study has found.
According to Business Insider, a woman living with HIV was found with 32 mutations to the virus, including some seen in variants of concern based on the study done by scientists.
The case report, which was not peer-reviewed, was published as a preprint on medRxiv on Thursday. The woman, who isn’t named, was identified as a 36-year-old living in South Africa.
The coronaviruses gathered 13 mutations to the spike protein, which is known to help the virus escape the immune response and 19 other mutations that could change the behaviour of the virus.
It is not clear whether the mutations she carried were passed on to others, the Los Angeles Times reported. Some of these mutations have been seen in variants of concern, such as:
- The E484K mutation is part of the Alpha variant (B.1.1.7 was first seen in the UK).
- The N510Y mutation is part of the Beta variant (B.1.351 was first seen in South Africa).
If more such cases are found, it raises the prospect that HIV infection could be a source of new variants simply because the patients could carry the virus for longer, Tulio de Oliveira, a geneticist at the University of KwaZulu-Natal in Durban and the study’s author told the LA Times.
But it is probably the exception rather than the rule for people living with HIV because prolonged infection requires severe immunocompromise, Dr Juan Ambrosini, an associate professor of infectious diseases at the University of Barcelona, told Insider. Indeed, the woman in the case study was immunosuppressed.
The findings are important in the fight against COVID-19 because these patients could be a continuous source of transmission and evolution of the virus, Ambrosini said.
HIV patients could carry the coronavirus longer than others especially those who are immunosuppressed
This case could easily have gone unnoticed, de Oliveira told the LA Times. This was because after the woman was treated in the hospital for her initial symptoms, she displayed only mild symptoms of COVID-19, even though she was still carrying the coronavirus, de Oliveira said.
Scientists only spotted this case because she was enrolled in a study of 300 people with HIV looking at their immune response to COVID-19. The researchers also found that four other people with HIV had carried the coronavirus for longer than a month, they told the LA Times.
Only one other case of a person with HIV carrying the coronavirus for a prolonged period had been published previously.
